Pharmacy practice is still in the very early stages of development in Nepal. Within the past 2 decades, there has been a considerable increase in the number of pharmacy colleges and pharmacy graduates; however, a clear career path for pharmacists is lacking. As such, the retention of pharmacists is an issue, as they may be tempted to move to more developed countries for better opportunities. Despite an increase in the number of pharmacy colleges and the number of pharmacists, certain aspects specifically related to hospital pharmacy still need improvement, such as training in hospital and clinical pharmacy, mentorship programs, and definition of career paths for pharmacists in both the public and private sectors. Beside this, pharmacy practice research is very important in addressing various issues such as the evaluation of new and existing services in patient care, pharmacoeconomics, and quality management. Although the value of academic research cannot be understated, it is important to realise that a great deal of research is conducted at grass roots level and the findings of such research can often impact on pharmacy practitioners in all settings. There is a need for more practice research to help the profession meet its aspirations.